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Some Gluten Facts in the Research

  • Celiac Disease is a permanent intolerance to gluten that results in immunologically mediated inflammatory damage to the small-intestine mucosa. - American Journal of Clinical Nutrition 1999;69:354-65
  • Celiac Disease is one of the most common lifelong disorders in both Europe and the US. - New England Journal of Medicine 348;25 June 19, 2003
  • Our findings suggest that CD is a much greater problem in the United States than has previously been appreciated. - Arch Intern Med/Vol 163, Feb 10, 2003
  • That gluten sensitivity is regarded as principally a disease of the small bowel is a historical misconception. - Journal Neurol Neurosurg Psychiatry 2002;72:560-563
  • Celiac Disease (CD) has also been termed Gluten Sensitive Enteropathy because the small intestine is the main target of injury; however, the clinical manifestations are extremely diverse, suggesting, the disorder is in fact a multi-system disorder. - Cell.Mol.Life Sci. 62(2005)791-799
  • The immune response triggered by sensitivity to gluten may find expression in organs other than the gut; and the central and peripheral nervous systems are particularly susceptible. - Journal Neurol Neurosurg Psychiatry 1997;63:770-775
  • Gluten sensitivity should be considered as a state of heightened immunologic responsiveness to ingested gluten proteins in genetically predisposed individuals.  The brain seems to be particularly vulnerable. - Pediatrics Vol. 108 No. 2, August 2001
  • CD 'out of the intestine' is even more frequent than CD 'within the intestine'. - Gastroenterology Vol. 126, No. 1, Jan. 2004, 359-361
  • Our data show for the first time that the prevalence of autoimmune disorders in celiac disease is related to the duration of exposure to gluten. - Gastroenterology 1999;117:297-303
  • All ADHD-like symptomatology patients should be tested for CD with serum screening tests, as CD could be one of the causes of these neuropsychiatric symptoms.  We are convinced that untreated CD may predispose to important mental and behavioral disorders. - Journal of Attention Disorders, March 2006, 1-5
  • Neurological disorders or findings were found in 51.4% of patients with CD. - Pediatrics Vol. 113, No. 6, June 2004
  • Fewer Celiac subjects had a university or college degree (5.3% vs. 22.8%); Fewer Celiac subjects worked in a managerial or professional positions (28% vs. 45%) - Scandinavian Journal of Gastroenterology, 2005;40:1407-1412
  • A review of all published studies from 1964 to 2000 (single and multiple case reports) of patients with established celiac disease who then developed neurological illness showed that the most commom neurological manifestations were ataxia and peripheral neuropathy. The thid most common was myopathy. - Muscle Nerve. 2007 Apr;.35(4):443-50
  • Patients with celiac disease were more prone to Hypotonia, Headache, Development Delay, Learning Disorders, ADHD, Epilepsy and Cerebellar Ataxia. - Pediatrics Vol. 113 No. 6 June 2004
  • Celiac disease in adults is often asymptomatic or presents with extremely few symptoms.  A high degree of clinical suspicion is required to make a prompt and correct diagnosis.  Cardiomyopathy associated with celiac disease is a serious and potentially lethal condition.  However, if diagnosed early, cardiomyopathy may be completely reversible with initiation of a gluten free diet. - Mayo Clinic Proc.-May 2005;80(5):674-676
  • Schizophrenia is frequently found in people with Celiac Disease and Celiac Disease is frequently found in people with schizophrenia.  In cultures where gluten grains are rarely eaten, schizophrenia is rare or non-existent. - British Medical Journal Volume 328; Feb. 21, 2004
  • If it remains unrecognized, celiac disease could increase the risk of life-threatening complications that are difficult to manage, such as intestinal lymphoma. - New England Journal of Medicine 348;25 June19, 2003
  • Death was most significantly affected by diagnostic delay, pattern of presentation, and adherence to the GFD(gluten free diet)...Non-adherence to the GFD, defined as eating gluten once-per-month increased the relative risk of death 600%. - Lancet.Vol.358, August 4, 2001
  • Celiac Disease should be considered in the differential diagnosis of patients presenting with proximal muscle weakness and diffuse musculoskeletal pain. - Clin Rheumatol (2005) 24:76-78
  • The prevelance of CD in osteoporosis is high enough to justify a recommendation for serologic screening (blood tests) of all patients with osteoporosis for celiac disease. - Arch Intern Med/Vol. 165, Feb. 28, 2005, 393-399
  • Many practitioners are not familiar with the many ways in which celiac disease presents or with the noninvasive methods available for identifying the disease. - Am J Clin Nutr 1999;69:354-65.
  • If CD is as common in the US as our study suggests, one must question why it is not diagnosed more frequently.  Foremost among the possible explanations is that is physicians believe that CD is rare, they are less likely to test for it. - Arch Intern Med/Vol 163, Feb 10, 2003
  • A failure by physicians to appreciate that many individuals with the disease initially present without gastrointensinal symptoms is another reason why CD testing may not be performed. - Arch Intern Med/Vol 163, Feb 10, 2003
  • The diagnosis of coeliac disease was made by a gastroenterologist in only 52.7% of cases and many other specialties are now recognizing this condition. - Prostgrad Med Journal 2002; 78: 31-33
  • The majority of Celiac patients had visited 5 or more doctors prior to diagnosis...and it had taken an average of 5 to 10 years, after initial presentation, for Celiac Disease to be diagnosed. - Kumar V, American Celiac Society, Nov. 9, 1996
  • A recently published survey of 1612 patients with CD in the US revealed that the average gap between the onset of symptoms and the time CD was confirmed was 11 years. - Arch Intern Med/vol 163, Feb. 10, 2003
  • Every time the disease is clinically diagnosed in an adult, that person has for decades had disease in a latent or silent stage. - New England Journal of Medicine Oct. 23, 2003, 1673-4
  • For every symptomatic patient with CD there are eight patients with CD and no gastrointestinal symptoms. - Gastroenterology 2001;120:636-651
  • Previously recognized largely as a childhood problem, it is now recognized to affect mostly adults, with about 25% of patients receiving their diagnosis at over 60 years of age. - British Medical Journal 205;330;739-40
  • Multiple studies suggest that patients with celiac disease should be treated, whether or not they have symptoms or associated conditions. - New England Journal of Medicine 348;25 June 19, 2003





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